Prediction of Neuropsychological Impairment in Multiple Sclerosis

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Abstract
Aprevious study by Rao et al1 showed that a linear measurement of the third ventricle derived from computed tomography was significantly correlated with cognition in multiple sclerosis (MS). More recent magnetic resonance imaging (MRI) studies demonstrated an association between lesion burden and cognitive impairment. In one study, T2 lesion area was a more significant predictor of most cognitive variables than either ventricular-brain ratio or corpus callosum size.2 Recently, T1 hypointense3 and fluid-attenuated inversion recovery (FLAIR)– defined lesions4 as well as whole-brain5 and bicaudate ratio6 atrophy measurements were correlated with cognitive impairment. Although cognitive dysfunction is correlated with measures of lesion burden and atrophy, it is unclear which dimension is most predictive.