Vasoconstrictor Action of Acetylcholine on Kidney Blood Vessels

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Abstract
Changes in the renal vascular resistance of cats and dogs have been studied employing a constant flow perfusion technique. Close intraarterial injections of acetylcholine, in large doses, usually greatly increase resistance. This effect is enhanced by neostigmine and abolished by atropine. It is not abolished by ganglionic blockade, adrenolytic agents or pretreatment of the animals with reserpine. The effect has been observed in kidneys with intact nerve supply as well as after denervation. When the action of acetylcholine is tested during an infusion of lidocaine into the renal artery, the response is slightly reduced. The mechanism of action is discussed and it is concluded that in this preparation the vasoconstrictor action of acetylcholine is due to a direct action on the vascular smooth muscle.