PREDOMINANCE OF MACROPHAGE-COLONY FORMATION IN HUMAN CORD BLOOD
- 1 January 1982
- journal article
- research article
- Vol. 10 (2) , 234-240
Abstract
To clarify understanding of the characteristics of granulopoiesis during early infancy, the colony-forming unit was investigated in culture (CFUC), in cord blood (CB), in peripheral blood (PB) and in bone marrow (BM) of infants. The macrophage-colonies (M-colonies) were always predominant in the study of colony formation by CB and PB cells from infants, regardless of the source of the CSF [colony stimulating factor] used. This result contradicts previous reports which concluded that the colonies were mainly granulocytic type. In the colony formation by BM cells from 1-mo.-old infants, the ratio of M-colonies was significantly higher than that of adult BM cells. The CSF produced by CB and PB mononuclear cells (MNC) from infants stimulated neutrophil-colony formation in the adult BM cells.This publication has 7 references indexed in Scilit:
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