l‐NG‐nitro arginine inhibits non‐adrenergic, non‐cholinergic relaxations of guinea‐pig isolated tracheal smooth muscle
Open Access
- 1 August 1990
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 100 (4) , 663-664
- https://doi.org/10.1111/j.1476-5381.1990.tb14072.x
Abstract
The effects of l-NG-nitro arginine (l-NOARG) on α-chymotrypsin-resistant, non-adrenergic, non-cholinergic (NANC) relaxations of guinea-pig tracheal smooth muscle have been examined. l-NOARG (1–100 μm), but not d-NOARG (100 μm), inhibited the NANC relaxations in a concentration-related manner. The effects of l-NOARG were partially reversed by l-arginine but not d-arginine.l-NOARG was without effect on acetylcholine-induced contractile responses of the trachea or on relaxations produced by vasoactive intestinal peptide, sodium nitroprusside or isoprenaline. These results suggest that an endogenous nitrate may contribute to NANC relaxations of tracheal smooth muscle.This publication has 11 references indexed in Scilit:
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