THE ACTION OF CYANIDE AND OF OXYGEN LACK ON GLOMERULAR FUNCTION IN THE PERFUSED FROG'S KIDNEY

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Abstract
Oliguria is frequently produced in the perfused frog''s kidney by the presence of cyanide in the arterial perfusion fluid or by the absence of O2 from it. Hober and his former colleagues in Kiel who discovered this found that the oliguria was not associated with corresponding decrease in rate of arterial perfusion. Since it occurred after tubule function had been abolished by brief renal portal perfusion with HgCl2 they concluded that the phenomenon was glomerular. Regarding arterial perfusion flow as a measure of glomerular perfusion, they concluded that significant change in glomerular perfusion flow or pressure did not occur; hence that glomerular urine is separated from blood not by filtration but by processes of secretion in the glomerular membrane which are re-versibly inhibited by CN or O2 lack. The present expts. indicate that in frogs a considerable no. of extrarenal arteries (those which do not supply glomeruli), both within and outside the kidneys, are reached by the arterial perfusion fluid in such expts. as those made in the Kiel laboratory; that these arteries are dilated by cyanide and O-lack; and that the glomerular arteries are constricted by these same agents. Hence glomerular perfusion flow and glomerular pressure may be decreased by these agents without a decrease in total arterial perfusion flow, and the oliguria which they produce can be explained as the result of diminished glomerular filtration.

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