Effects of interacting variables on the tensile strengths and disintegration times of paracetamol tablets
- 1 December 1985
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 37 (12) , 903-905
- https://doi.org/10.1111/j.2042-7158.1985.tb04998.x
Abstract
The effects of separately varying the packing fraction (P), the proportions of microcrystalline cellulose, Avicel (A) and alginic acid, disintegrant (D), on both the tensile strengths and disintegration times of paracetamol tablets are in the order P » A » D. The combined effects of these variables on both tensile strength and disintegration time are A x P » D x P > A x D.Keywords
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