State-Dependent Effects of β-Endorphin on Core Temperature in Stressed and Non-Stressed Rats
Open Access
- 1 January 1985
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 39 (3) , 395-396
- https://doi.org/10.1254/jjp.39.395
Abstract
β-Endorphin, γ-endorphin, δ-endorphin and morphine injected i.c.v. caused hyperthermia in non stressed rats; however, the same dose of β-endorphin and morphine caused hypothermia in stressed animals. These effects of β-endorphin were antagonized by naloxone. The results suggest that effects of β-endorphin are different depending on the animal's state and that these effects are mediated via opioid receptors.Keywords
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