ACETATE INCORPORATION INTO CHOLESTEROL AND FATTY ACIDS BY LIVER SLICES FROM RATS FED COMMERCIAL OR SEMISYNTHETIC DIETS: THE EFFECT OF DIETARY FATS

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Abstract
Liver slices from rats fed a commercial diet incorporated more acetate-1-C14 into cholesterol than did slices from rats fed semisynthetic diets. The stimulatory effect of the commercial diet was due in part to a saponifiable component of the ether-soluble portion of the diet, possibly linoleic acid; and in part to the ether-insoluble portion of the diet. Dietary fats stimulated acetate incorporation into cholesterol more when mixed with the ether-insoluble portion of commercial diet than when mixed with semisynthetic diet. With either diet, unsaturated fats stimulated incorporation more than saturated fats. The rate-limiting step in these experiments was prior to mevalonic acid in the cholesterol biosynthetic pathway. Acetate incorporation into fatty acids was little affected by the nature of the dietary fat or the diet in which it was fed.
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