A Non-cryogenic Method for the Preparation of 2-(Indolyl) Borates, Silanes, and Silanols
- 18 September 2002
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 67 (21) , 7551-7552
- https://doi.org/10.1021/jo026087j
Abstract
2-Indolyl borates are prepared via addition of LDA to a mixture of N-Boc-indole and triisopropyl borate at 0−5 °C. Following acidic hydrolysis, the boronic acids are isolated by crystallization in good to excellent yield (73−99%). The method is quite general, tolerating a wide range of functional groups, and also provides access to 2-silyl derivatives (80−91%).Keywords
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