Effects of Vasoactive Drugs and Nerve Stimulation on Blood Flow in the Tooth Pulp and Allied Structures of the Cat

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Abstract
The vasopressor drug epinephrine, administered both locally and systemically, can alter mandibular and pulpal blood flow, with or without concomitant change in systemic pressure. Amyl-nitrite, isoproterenol and methacoline were the vasodepressor drugs used in this study. Comparison of the results obtained with these drugs indicated that changes in local resistance, cardiac output and cardiac rate influence the direction of blood flow change in the pulp and related structures. Stimulation of the peripheral end of the cervical sympathetic nerve reduced the blood flow in the tooth pulp and ear, with no significant change in mandibular blood flow. A marked increase in intensity of stimulation resulted (in some experiments) in a greater decrease in mandibular flow.

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