Eukaryotic ribosomes can recognize preproinsulin initiation codons irrespective of their position relative to the 5′ end of mRNA
- 1 September 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 299 (5880) , 221-226
- https://doi.org/10.1038/299221a0
Abstract
The functional assay of a eukaryotic [rat] mRNA, into which additional AUG codons have been introduced by in vitro mutagenesis, shows that a translational initiation site need not necessarily be the nearest AUG codon to the 5'' end of a mRNA. Hence, the sequence surrounding the AUG, and not simply its position relative to the 5'' end of mRNA, appears to be important in determining initiation efficiency.This publication has 27 references indexed in Scilit:
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