Isolation and characterization of I5B2, a new phosphorus containing inhibitor of angiotensin I converting enzyme produced by Actinomadura sp.
- 1 January 1984
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 37 (9) , 965-969
- https://doi.org/10.7164/antibiotics.37.965
Abstract
A new inhibitor of angiotensin I converting enzyme, 15B2, was isolated from the culture broth of Actinomadura sp. No. 937ZE-1. This compound contains N-methylvaline, tyrosine and 1-amino-2-(4-hydroxyphenyl)ethylphosphonic acid. The microorganism also produced another inhibitor, I5B1, which is identical with K-4 isolated from Actinomadura sp. as an antihypertensive agent.This publication has 3 references indexed in Scilit:
- Muraceins - Muramyl peptides produced by Nocardia orientalis as angiotensin-converting enzyme inhibitors I. Taxonomy, fermentation and biological properties.The Journal of Antibiotics, 1984
- Inhibition of angiotensin converting enzyme by phosphonic amides and phosphonic acidsBiochemistry, 1983
- Isolation and characterization of ancovenin,a new inhibitor of angiotensin I converting enzyme,produced by Actinomycetes.The Journal of Antibiotics, 1983