• 1 January 1977
    • journal article
    • research article
    • Vol. 36  (2) , 245-255
Abstract
On isolated coronary arteries of cattle, nitroprusside-sodium, nitroglycerol, prenylamine and verapamil were studied for their spasmolytic effects on a contracture induced by F-. With this contracture model, which is independent of extracellular Ca, nitroprusside-sodium and nitroglycerol showed strong spasmolytic action. Verapamil proved ineffective and the effectiveness of prenylamine was strongly reduced. Nitroglycerol and nitroprusside-sodium apparently are endowed with a relaxation mechanism different from that of verapamil and analogously acting compounds.