Morphine compared with diamorphine

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Abstract
The dose requirements and side effects of morphine were compared with those of diamorphine administered by patient‐controlled analgesia in 40 patients following elective total hip replacement. Patients were allocated randomly to receive in a double‐blind manner either morphine or diamorphine for postoperative pain relief. There were no significant differences between the two groups with regard to postoperative sedation, nausea, well‐being, pain relief and requirements for antiemetic drugs. The dose requirement for diamorphine was approximately 50% of that for morphine.

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