Effect of hemolysis on excretion and accumulation of iron in the rat

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Abstract
Two groups of rats were injected intraperitoneally with tracer amounts of Fe59 Cl3 and the rate of loss of radioactivity was measured over a period of 105 days. Both groups of rats were maintained on a regular rat pellet diet but the experimental group also received acetylphenylhydrazine weekly in order to induce hemolytic disease. At the end of the experiment all rats were killed and the body iron content of each determined. It was observed that the fraction of body iron lost daily was markedly increased in rats undergoing hemolysis. Further, these rats accumulated iron in excess of normal, indicating that iron absorption was increased to a greater extent than was iron excretion.

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