ISOSORBIDE IN THE MANAGEMENT OF INFANTILE HYDROCEPHALUS
- 12 November 2008
- journal article
- research article
- Published by Wiley in Developmental Medicine and Child Neurology
- Vol. 25 (4) , 502-511
- https://doi.org/10.1111/j.1469-8749.1983.tb13797.x
Abstract
Experience with 101 hydrocephalic infants treated primarily with isosorbide is reported. For those with moderate hydrocephalus the aim was to avoid shunt surgery and this was achieved in 31 of the 43 infants. In cases with severe hydrocephalus or when the CSF was abnormal the aim was to delay shunt surgery until the optimum time, with a lower risk of complications. Five of 48 such infants avoided shunts and 30 achieved a worthwhile delay. Nine other chlidren were treated with isosorbide following shunt complications. Toxic effects were infrequent, not severe and reversible on stopping treatment or reducing dosage. A total of 63 infants eventually had shunts inserted.This publication has 23 references indexed in Scilit:
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