The synthesis of oligoribonucleotides VI. The synthesis of a hexadecamer by a block condensation approach
- 15 July 1980
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 58 (14) , 1389-1397
- https://doi.org/10.1139/v80-219
Abstract
The synthesis of the 5′-monomethoxytrityl-2′-tert-butyldimethylsilyl-3′-levulinylribonucleosides 4 of the four major bases involved in the phosphite procedure for the synthesis of oligoribonucleotides is described along with the 2′,3′-isomeric derivatives 6. This report describes a total protection system for nucleotide units which allows for the block condensation procedure to be used for the synthesis of long chains. The procedure is illustrated by the synthesis of a hexadecauridylic acid.This publication has 5 references indexed in Scilit:
- The synthesis of oligoribonucleotides V. The stepwise synthesis of the 3′-terminal heptanucleotide sequence of tRNAfMet from E. coliCanadian Journal of Chemistry, 1979
- The synthesis of oligoribonucleotides. III. The use of silyl protecting groups in nucleoside and nucleotide chemistry. VIIICanadian Journal of Chemistry, 1979
- Studies on transfer ribonucleic acids and related compounds. 23. Synthesis of a heptanucleotide corresponding to a eukaryotic initiator tRNA loop sequenceJournal of the American Chemical Society, 1978
- The synthesis of oligoribonucleotides. II. The use of silyl protecting groups in nucleoside and nucleotide chemistry. VIICanadian Journal of Chemistry, 1978
- Oligoribonucleotide synthesis. X. An improved synthesis of the anticodon loop region of methionine transfer ribonucleic acid from E. coliCanadian Journal of Chemistry, 1976