Rat gastric acid secretion in response to graded subcutaneous doses of 2-deoxy-D-glucose

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Abstract
Gastric acid secretion in response to single subcut. injections of the vagal stimulant 2-deoxy-D-glucose (2DGlc) was measured in pylorus-ligated rats. Doses ranged from 0 to 800 mg 2DGlc/kg rat weight. 2DGlc was shown to be an effective stimulant of gastric secretion by the pylorus-ligated rat, its effect over a 4-hr. collecting period being to increase the volume rather than the acidity of gastric juice. Maximum secretion occurred following an injection of 600 mg 2DGlc/kg. Study of gastric acid secretion 0-2 hr. and 3-4 hr. after injection demonstrated that the drug, though effective during both periods, exerted a more powerful effect on gastric secretion during the 3rd and 4th hr. after injection.