Effect of Histamine on Gastric Secretion in the Pylorus Ligated Rat

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Abstract
Summary The effects of single large subcutaneous doses (50 mg/kg) of histamine acid phosphate on gastric secretion were studied in pylorus ligated rats. Significant increases in gastric acidity and acid production were observed 2 hours after histamine injection. No differences between control and histamine injected rats were found 4 hours after injection. Study of the secretory patterns indicated that histamine caused early increased secretion of acid followed by a period of secretory inactivity while, in control rats, the secretory rate increased with time so that by 4 hours gastric secretion was equal in all groups. The gastric secretory stimulation was shown to be due to the histamine and not to the fluid in which it was contained. These studies help reconcile the differing results previously reported concerning the effects of histamine on the rat stomach and suggest that the standard 4-hour pylorus ligated rat preparation may not be suited for experiments utilizing histamine.