Transphosphorylations catalysed by bivalent metal ions
- 1 October 1958
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 70 (2) , 222-230
- https://doi.org/10.1042/bj0700222
Abstract
A non-enzymic transphosphorylation between adenosine triphos-phate and orthophosphate was demonstrated. The reaction is catalyzed by bivalent metal ions. Of those tested, Mn++, Ca++ and Cd++ were found the most effective. The reaction has a sharp pH optimum. With Mn-- ions the rate of transphosphorylation is optimum at adenosine triphosphate/metal ratios between 0.6 and 1.0. A mechanism is proposed for the reaction, and its relation to enzymic transphosphorylation is discussed.Keywords
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