The Effect of Whole-Body X-Irradiation on the Absorption of Calcium-45 and Strontium-85 from the Intestinal Tract of the Rat

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Abstract
Young and mature male albino rats were given whole-body X-irradiation (285 kvp) to determine whether the absorption of radiostrontium and radiocalcium could be altered. Two hundred r significantly increased the amount of Sr85 and Ca45 crossing the intestine of the young rat, but 1000 r and 400 r were needed in the mature rat to increase the passage of Sr85 and Ca45, respectively. Irradiation did not alter the uptake of the radionuclides by bone, and it was concluded that the defect was produced at the intestinal level. The increased absorption of radiostrontium and radiocalcium was evident as early as 2 hours and as long as 48 hours after irradiation. Feeding and/or fasting the animals before and after irradiation had no effect on the results.