Effect of Diet on Oxidation of 17β-Estradiolin Vivo*

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Abstract
The effect of a high fat, low carbohydrate, low protein diet on the in vivo oxidation of 17.beta.-estradiol was studied using radiometric methods. Five male chimpanzees were fed a normal (13%) fat diet or a high (65%) fat diet for 8 weeks. After a 4-week rest period, the animals were fed the alternative diet. The mean percent oxidation of 16.alpha.-[3H]estradiol-17.beta. 24 h after injection was 3.8 .+-. 1.3% (.+-.SD) on the normal diet vs. 18.4 .+-. 4.7% on the high fat diet (P < 0.01). In contrast, the mean percent oxidation of 2-[3H]estradiol 24 h after injection was 31.6 .+-. 3.8% (.+-.SD) on the normal diets vs. 20.0 .+-. 3.5% on the high fat diet (P < 0.05). These results suggest that the oxidation of 17.beta.-estradiol to estriols relative to that to catechol estrogens is increased by a high fat diet.