Transcript levels of theSaccharomyes cerevisiaeDNA repair geneRAD23increase in response to UV light andin meiosis but remain constant in the mitotic cell cycle
- 1 January 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 18 (16) , 4737-4742
- https://doi.org/10.1093/nar/18.16.4737
Abstract
The RAD23 gene of Saccharomyces cervisiae is required for excision-repair of UV Damage DNA. In this paper, we determine the location of the RAD23 gene in a cloned DNA fragment, identify the 1.6 kb RAD23 transcript, and examine RAD23 transcript levels in UV damaged cells, during the mitotic cell cycle, and in meiosis at a stage conicident with high levels of genetic recombination. This response is specific to sporulation competent MATa/MAT.alpha. diploid cells, and is not observed in asporogenous MATa/MATa diploids. RAD23 mRNA levels, however, remain constant during the mitotic cell cycle.Keywords
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