Effect of nifedipine on digoxin kinetics in healthy subjects
- 1 November 1982
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 32 (5) , 562-565
- https://doi.org/10.1038/clpt.1982.203
Abstract
Verapamil reduced total-body digoxin clearance by 35% due to impairments of both renal and extrarenal clearances. The influence of the related Ca antagonist nifedipine was evaluated on single-dose digoxin kinetics. Nifedipine increased extrarenal clearance of digoxin from 1.09 .+-. 0.30(SD) to 1.45 .+-. 0.23 ml/min per kg (P < 0.05) and reduced the total urinary recovery of the drug from 69.2% .+-. 5.9 to 64.3% .+-. 5.2 (P < 0.05). There were no significant changes in renal digoxin clearance, distribution or biological half-life or in digoxin distribution volumes during nifedipine coadministration.This publication has 1 reference indexed in Scilit:
- Reduction of digoxin-induced inotropism during quinidine administrationClinical Pharmacology & Therapeutics, 1980