Microbial mutagenicity of isomeric two‐, three‐, and four‐ring amino polycyclic aromatic hydrocarbons

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Abstract
The isomers of various two‐, three‐, and four‐ring amino polycyclic aromatic hydrocarbons were tested for mutagenic activity using a microbial plate incorporation test with four Salmonella typhimurium strains (TA98, TA 100, TA1535, and TA 1537). All compounds were assayed with an S9 metabolic activating enzyme system. The two‐ring compounds were tested only with TA98. All were weakly mutagenic (1–10 rev/μg) except 2‐aminobiphenyl, which was not mutagenic under these test conditions. All except two of the 13 fused three‐ring compounds (aminofluorenes, aminoanthracenes, and aminophenanthrenes) were active frame shift mutagens; only the aminophenanthrenes were active base‐pair mutagens. The potency of this group of isomeric compounds ranged from moderately (˜ 20 rev/μg) to strongly (> 5,000 rev/μg) mutagenic. As a group, the pericondensed fourring amino compounds were the most mutagenic of the three groups tested. All of the aminofluoranthene and aminopyrene isomers showed significant mutagenic activity with TA98, TA100, and TA1537. In general, the mutagenic potency of the amino polycyclic aromatic compounds tested was highly dependent on the structural position of the amino group.