Micromotility meter: an instrument designed to evaluate the action of drugs on motility of larval and adult nematodes
- 1 August 1986
- journal article
- research article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 93 (2) , 341-346
- https://doi.org/10.1017/s0031182000051507
Abstract
SUMMARY: An instrument for measuring the motility of larval and adult nematodes is described along with an analysis of its use as a tool to analyse drug action on these parasites. Motility was detected from larval parasites ofNippostrongylus brasiliensisandAscaris suumin the absence and presence of various anti-nematodal drugs. These agents produced, within 48 h, a significant decrease in larval parasite motility. The instrument was also capable of detecting the motility ofCaenorhabditis elegans, adult femaleBrugia pahangiand their response to anti-nematodal drugs. The design of the instrument allows us to accurately measure motility in a single sample within 60 sec.This publication has 13 references indexed in Scilit:
- The relevance of in vitro anthelmintic screening tests employing the free-living stages of trichostrongylid nematodesJournal of Helminthology, 1984
- Dipetalonema viteae (Nematoda: Filarioidea): Culture of Third-Stage Larvae to Young Adults in VitroScience, 1983
- An in vitro screen for anthelmintics employing Nippostrongylus brasiliensis in a defined mediumVeterinary Parasitology, 1982
- The use ofCaenorhabditis elegansfor anthelmintic screeningJournal of Chemical Technology & Biotechnology, 1981
- A new primary screening test for anthelmintics utilizing the parasitic stages ofNippostrongylus brasiliensis, in vitroZeitschrift Fur Parasitenkunde-Parasitology Research, 1980
- Schistosoma mansoni: Direct method for simultaneous recording of electrical and motor activityExperimental Parasitology, 1977
- Anin vitroactivity monitor for schistosomes: preliminary reportPathogens and Global Health, 1973
- A preliminary in vitro test for anthelmintic activityExperimental Parasitology, 1958