Disopyramide Anticholinergic Action

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Abstract
The effect of disopyramide on cholinergic transmission has been studied using the frog isolated abdominis rectus preparation and the guinea pig isolated vas deferens hypogastric nerve preparation. Disopyramide (2 × 10‐5mol litre‐1) reduced the response of the abdominis rectus to carbachol (1.36 × 10‐6— 4.8 × 10‐5mol litre‐1). Furthermore, disopyramide (1 × 10‐6—3 × 10‐4mol litre‐1) produced a concentration‐dependent reduction in the response to carbachol (5.46 × 10‐6mol litre). The response to potassium chloride (3.34 × 10 mol litre‐1) was unaltered by disopyramide (1 × 10 —3 × 10‐4mol litre‐1). Disopyramide produced a dose‐related ganglionic blockade at concentrations greater than 2 × 10‐5mol litre‐1. Complete blockade to ganglionic transmission occurred at 3 × 10‐4mol litre‐1disopyramide.