Physiologic Availability of Riboflavin and Thiamine in “Chewable” Vitamin Products
Open Access
- 1 March 1962
- journal article
- research article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 10 (3) , 212-216
- https://doi.org/10.1093/ajcn/10.3.212
Abstract
The physiologic availability of riboflavin and thiamine was determined in a number of “chewable” vitamin preparations. Of nine products studied, six showed incomplete availability of riboflavin, as measured by urinary excretion of the vitamin by human subjects. Of these, four were coated products or preparations containing them, while the other two were a riboflavin resin and a product containing riboflavin resin. Thiamine was fully available in all products studied. Two coated riboflavin products and a riboflavin resin found only partially available in man were fully available for growth in the rat. It was concluded that (1) any process used to coat or otherwise modify the rate of release of a vitamin for human use should be tested in man to ensure that the availability of the vitamin is not affected; (2) any process which interferes with the disintegration or solution of a vitamin product in the gastrointestinal tract may have a marked effect on the physiologic availability of riboflavin.Keywords
This publication has 11 references indexed in Scilit:
- Physiologic Availability and in Vitro Release of Riboflavin in Sustained-Release Vitamin PreparationsNew England Journal of Medicine, 1960
- The Relationship Between Physiological Availability of Salicylates and Riboflavin and In Vitro Disintegration Time of Enteric Coated Tablets**Recrived October 2, 1959, from the Food and Drug Laboratories, Department of National Health and Welfare, Ottawa, Ontario, Canada.Journal of the American Pharmaceutical Association (Scientific ed.), 1960
- Further Studies on the Relation Between in Vitro Disintegration Time of Tablets and the Urinary Excretion Rates of Riboflavin**Food and Drug Laboratories, Department of National Health and Welfare, Ottawa, CanadaJournal of the American Pharmaceutical Association (Scientific ed.), 1959
- ORAL DEPOT THERAPY WITH A NEW LONG-ACTING DEXAMPHETAMINE SALTThe Lancet, 1957
- Sulfaethylthiadiazole II.**Smith, Kline & French Laboratiores, and the University of Pennsylvania School of Medicine, Philadelphia, Pa.Journal of the American Pharmaceutical Association (Scientific ed.), 1957
- The Relation Between in Vitro Disintegration Time of Sugar-Coated Tablets and Physiological Availability of Riboflavin*Journal of the American Pharmaceutical Association (Scientific ed.), 1954
- Availability of Riboflavin of Ice Cream, Peas, and Almonds Judged by Urinary Excretion of the Vitamin by Women SubjectsJournal of Nutrition, 1948
- Vitamin Absorption StudiesJournal of Nutrition, 1945
- Physiological Availability of the VitaminsJournal of Nutrition, 1945
- The Role Played by the Gastrointestinal Tract in the Absorption and Excretion of RiboflavinJournal of Nutrition, 1943