STUDIES ON THE CONTROL OF THE RENAL TUBULAR TRANSPORT OF p-AMINOHIPPURATE BY THE ANTERIOR PITUITARY1

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Abstract
Hypophysectomy reduced PAH uptake of renal slices of the rat. The evidence presented indicates that besides a renotropic factor of pituitary origin (possibly growth hormone) the depression of thyroid and testicular function are operative in the decrease in the PAH transport capacity of the kidney. Adrenalectomy of normal rats had no influence on renal PAH transport. ACTH, cortisone or DCA therapy of hypophysectomized rats did not restore renal PAH transport. Acetate oxidation and utilization for PAH transport are depressed by hypophysectomy. It is likely that the depression of thyroid function is important in this phenomenon. Small amounts of thyroxin (1-2 [mu]g/rat) when given to hypophysectomized rats mainly restore acetate induced stimulation of PAH transport and O2 consumption.