A case of neuromyelitis optica (Devic's syndrome) in systemic lupus erythematosus

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Abstract
An interesting [human] case of systemic lupus erythematosus (SLE) is presented in which the clinical onset of myelopathy strongly suggested demyelinating disease. Later, intracranial hypertension developed on 2 occasions. Postmortem examination showed the systemic lesions of SLE. Demyelinating lesions were found in the spinal cord and the optic nerve, the neuropathologic picture of Devic''s syndrome, a variant of multiple sclerosis. The possibility is discussed that some previously reported cases showing necrotic myelopathy might have an autoimmune pathogenesis.

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