Effect of Intraperitoneal ATP on Tumor Growth and Bone Marrow Radiation Tolerance
- 1 January 1995
- journal article
- research article
- Published by Taylor & Francis in Acta Oncologica
- Vol. 34 (3) , 419-422
- https://doi.org/10.3109/02841869509094001
Abstract
Transplants of a spontaneous murine fibrosarcoma (FSaII) treated with intraperitoneal ATP were studied in vitro, and in both C3H and nu/nu mice. Daily ATP treatment prolonged tumor volume doubling time in vivo and in vitro. Daily ATP treatments at the maximally tolerated dose (2 mmol/kg i.p.) did not significantly affect the pH or the PCr/Pi, or beta ATP/Pi ratios (measured by MRS). In contrast to the reduced tumor growth rate, there was no change in bone marrow recovery after whole body irradiation. ATP is minimally toxic to animals at active dose levels. It slows tumor growth rate without adversely affecting bone marrow radiation tolerance. ATP might therefore be useful as a biological modifier of chemotherapy or radiation therapy.Keywords
This publication has 14 references indexed in Scilit:
- Tumor growth retardation and pathophysiological effects of adenosine 5′‐triphosphate therapy measured by thallium washout, 31P nuclear magnetic resonance, laser doppler flowmetry, and intradermal angiogenesisRadiation Oncology Investigations, 1993
- P2-purinergic receptor agonists inhibit the growth of androgen-independent prostate carcinoma cells.Journal of Clinical Investigation, 1992
- Cytotoxic effect of 1,3 bis (2-chloroethyl)-N-nitrosourea at elevated temperatures: Arrhenius plot analysis and tumour responseInternational Journal of Hyperthermia, 1991
- Mechanisms of Anticancer Activities of Adenine Nucleotides in Tumor‐Bearing HostsAnnals of the New York Academy of Sciences, 1990
- Extracellular adenosine 5′-triphosphate-evoked norepinephrine secretion not relating to voltage-gated Ca channels in pheochromocytoma PC12 cellsNeuroscience Letters, 1989
- Extracellular adenosine triphosphate activates calcium mobilization in human phagocytic leukocytes and neutrophil/monocyte progenitor cells.Journal of Clinical Investigation, 1989
- Effects of Hydralazine-Induced Vasodilation on the Energy Metabolism of Murine Tumors Studied by In Vivo31P-Nuclear Magnetic Resonance Spectroscopy1JNCI Journal of the National Cancer Institute, 1988
- Characteristics of Analgesia Induced by Adenosine TriphosphateBasic & Clinical Pharmacology & Toxicology, 1987
- Inhibition of Tumor Growth by Nucleoside Cyclic 3′,5′-MonophosphatesHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1969
- Inhibition of Cell Growth in vitro by Adenosine 3′,5′-MonophosphateScience, 1968