Tissue transplantation immunity in the adult newt, Diemictylus viridescens. II. The rejection phase: First‐ and second‐set allograft reactions and lack of sexual dimorphism

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Abstract
Rejection of first‐set allografts in field collected Diemictylus viridescens is manifested by: (1) secondary vessel dilation (about 17 days), (2) hemostasis (about 20 days), (3) hemorrhage (about 23 days), and (4) eventual melanophore death (from 28 to 40 days). All these events were somewhat variable with respect to the time of onset, intensity, and duration. Histologically, these changes that distinguished allografts from autografts were paralleled by: (1) an increasing infiltration of small lymphocytes without graft destruction (secondary vasodilation), and (2) a stronger infiltration of lymphocytes concomitant with glandular death (hemostasis, hemorrhaging, and melanophore death). Although this pattern of rejection was the norm, several examples of long‐term graft survival were encountered.When 28 days separated the transplantation of single first‐ and second‐set grafts, a clear anamnestic response was elicited although circulation was re‐established in 58% of the secondary transplants. Specificity of the second‐set response was demonstrated.Single second‐set transplants grafted ten days after single first‐set grafts were not rejected in an accelerated fashion; rather such grafts often survived for a few days longer than the first‐set grafts transplanted to the same host.The rejection of allografts from donors of different sexes transplanted to hosts of both sexes did not reveal any sexual dimorphic response. The site of transplantation (flank or throat) did not alter the timing or sequence of the rejection pattern.