Alleviation of mechanical and thermal allodynia by CGRP8-37 in a rodent model of chronic central pain
- 1 May 2000
- journal article
- research article
- Published by Wolters Kluwer Health in PAIN®
- Vol. 86 (1) , 163-175
- https://doi.org/10.1016/s0304-3959(00)00242-6
Abstract
CGRP8-37 is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor and is a highly selective CGRP receptor antagonist. CGRP and activation of its receptor appear to play a role in peripheral inflaKeywords
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