PROMOTION BY L-ASCORBIC-ACID OF URINARY-BLADDER CARCINOGENESIS IN RATS UNDER CONDITIONS OF INCREASED URINARY K ION CONCENTRATION AND PH
- 15 September 1987
- journal article
- research article
- Vol. 47 (18) , 4821-4824
Abstract
Dietary administration of 5% L-ascorbic acid plus 3% K2CO3 to male F433 rats clearly enhanced the development of preneoplastic and neoplastic lesions of the urinary bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Promotion of carcinogenesis by L-ascorbic acid and K2CO3 was associated with changes in urinary parameters: elevation of pH, increased K+ concentration, and increase in total ascorbic acid.This publication has 8 references indexed in Scilit:
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