ENHANCEMENT BY URINE OF URINARY-BLADDER CARCINOGENESIS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 41  (2) , 478-481
Abstract
The role of urine as a tumor-enhancing agent in urinary bladder carcinogenesis was investigated by using the heterotopically transplanted rat urinary bladder. Bladders removed from rats initiated with the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine in drinking water for 4 or 10 wk were heterotransplanted to syngeneic rats. Those heterotopically transplanted bladders receiving repeated instillations of normal rat urine subsequent to transplantation had a higher incidence of carcinoma than did those receiving 0.9% NaCl solution. Normal urine may contain tumor promoter(s).