Increased blood-brain barrier dysfunction around cerebral stab wounds in rats immunized to brain antigens
- 29 January 2009
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 66 (4) , 482-487
- https://doi.org/10.1111/j.1600-0404.1982.tb06870.x
Abstract
The extravasation of serum albumin and IgG was assayed by electroimmunoassay in cerebral cortex homogenates of rats subjected to stab wound injury either 2 wk after immunization to brain antigens or without prior immunization. The amount of IgG in the brain was significantly higher in immunized rats 3 and 24 h after injury. A significantly enhanced extravasation of albumin in immunized rats was found only after 24 h. Immunization to brain antigens enhances the vulnerability of the blood-brain barrier in rats subjected to stab wound injury.Keywords
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