Erythropoietin: Hypothesis of Action Tested by Analog Computer
- 15 April 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 152 (3720) , 367-370
- https://doi.org/10.1126/science.152.3720.367
Abstract
The action of erythropoietin on the pool of undifferentiated bone marrow cells has been examined with the aid of a model tested with an analog computer. The model is consistent with reported experimental results. The essential aspects of the action are (i) the effect is exerted during the S phase of the cell's cycle; (ii) " effective " erythropoietin is present in the cell only during G1 and part of S; and, (iii) hormone molecules survive in the cell for only a limited time in effective form and require a certain time to assume this form.This publication has 13 references indexed in Scilit:
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