Comparison of Anti-Granuloma, Thymolytic and Glucocorticoid Activities of Anti-Inflammatory Steroids

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Abstract
Summary A series of 15 corticoids was assayed for anti-granuloma, thymolytic and liver glycogen deposition activities in adrenalectomized male rats. The order of relative potency for the majority of the steroids was similar in the three bioassays. Exceptions were 6α-chloro-9α-fluoro-16α-hydroxyprednisolone acetonide acetate and 6α-fluoro-16α-methylprednisolone which had greater relative potencies in the anti-granuloma and thymolytic assays, and 9α-fluoro-16α-hydroxyprednisolone acetonide which had a greater relative potency in the liver glycogen deposition assay.