THE INFLUENCE OF ADRENALECTOMY AND INDIVIDUAL STEROID HORMONES UPON THE METABOLISM OF ACETATE-1-C14BY RAT LIVER SLICES: II. INCORPORATION INTO CHOLESTEROL

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Abstract
A study has been made of the effect of adrenalectomy upon cholesterol synthesis by rat liver slices. An increased incorporation of acetate-1-C14was observed in adrenalectomized control animals, and in all groups of adrenalectomized rats treated with the steroid hormones under investigation. Deoxycorticosterone was the only hormone used which raised cholesterogenesis from acetate above the level of the adrenalectomized control group: this effect was not observed using mevalonate-2-C14as substrate. In groups of sham-operated animals, deoxycorticosterone, progesterone, and Reichstein's substance S increased acetate incorporation above the level attained by the control group. In a comparison of the effects of certain steroid acetates, Reichstein's substance S acetate and deoxycorticosterone acetate stimulated cholesterogenesis above the levels of the corresponding controls in both sham-operated and adrenalectomized animals, though the effect of the latter hormone was not as pronounced as when the alcohol form was used.