Escherichia coli Cells Bearing a Ribosomal Ambiguity Mutation in rpsD Have a Mutator Phenotype That Correlates with Increased Mistranslation
Open Access
- 15 August 2003
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 185 (16) , 5015-5018
- https://doi.org/10.1128/jb.185.16.5015-5018.2003
Abstract
Escherichia coli cells bearing certain mutations in rpsD (coding for the 30S ribosomal protein S4) show a ribosomal ambiguity (Ram) phenotype characterized by increased translational error rates. Here we show that spontaneous mutagenesis increases in Ram cells bearing the rpsD14 allele, suggesting that the recently described translational stress-induced mutagenesis pathway is activated in Ram cells.Keywords
This publication has 29 references indexed in Scilit:
- DNA Polymerase III from Escherichia coliCells Expressing mutA Mistranslator tRNA Is Error-proneJournal of Biological Chemistry, 2002
- Mistranslation induced by streptomycin provokes a RecABC/RuvABC-dependent mutator phenotype in Escherichia coli cells 1 1Edited by M. GottesmanJournal of Molecular Biology, 2002
- The miaA Mutator Phenotype of Escherichia coli K-12 Requires Recombination FunctionsJournal of Bacteriology, 2001
- A novel mutation in ribosomal protein S4 thataffects the function of a mutated RF1Biochimie, 2000
- Requirement for Homologous Recombination Functions for Expression of the mutA Mistranslator tRNA-Induced Mutator Phenotype in Escherichia coliJournal of Bacteriology, 2000
- S4-16 S ribosomal RNA complexJournal of Molecular Biology, 1989
- Assembly of the 30S subunit from Escherichia coli ribosomes occurs via two assembly domains which are initiated by S4 and S7Biochemistry, 1988
- Regulation of α operon gene expression in Escherichia coliJournal of Molecular Biology, 1987
- Genetic studies of the lac repressorJournal of Molecular Biology, 1977
- A ribosomal ambiguity mutationJournal of Molecular Biology, 1969