Decreased Correlation Between the Agarose Leukocyte Migration Inhibition Assay and Delayed Cutaneous Hypersensitivity Response to Purified Protein Derivative in Cancer Patients2

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Abstract
Studies were done to evaluate the degree of correlation between the agarose leukocyte migration inhibition (LMI) assay and the delayed cutaneous hypersensitivity (DCH) response to purified protein derivative (PPD) in normal donors and cancer patients. Leukocytes from 19/21 (91%) PPD-positive normal donors were LMI-positive, whereas leukocytes from 10/11 (91%) PPD-negative normal controls were LMI-negative. In contrast, the leukocytes of 11114 (79%) PPD-positive untreated cancer patients were LMI-positive and those of 10/15 (67%) untreated PPD-negative cancer patients were LMI-negative. The difference between the leukocytes of the PPD-positive normal donors and those of the PPD-positive cancer patients was significant (PP0.05) or between the reactivity of the PPD-posltlve cancer patients and that of the PPD-positive BCG-treated cancer patients (P>0.20). Leukocytes from 2 PPD-negatlve BCG-treated cancer patients were LMI-negative, a number too small for valid statistical comparison. The neoplastic process seemed to cause a discrepancy between the agarose LMI and DCH responses in cancer patients, and BCG immunotherapy appeared to have a minimal effect on this relationship.

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