Some effects of cocaine on the metabolism of Saccharomyces cerevisiae

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Abstract
The effects of cocaine and of added vit. B1 on the glucose fermentation of S. cerevisiae at pH 7, previously grown in the presence and in the absence of cocaine, were compared. There is a difference in behavior towards added vit. B1 between normal and cocaine-grown yeast. Cocaine in concn. sufficient to arrest growth (0.005 [image]) at pH 7 inhibits completely the carboxylase system of S. cerevisiae. The carboxylase systems of yeast grown in the presence and in the absence of cocaine are inhibited by cocaine to a similar extent. No quantitative adaptation of the carboxylase system of S. cerevisiae was found as a result of growth in the presence of cocaine at pH 7.