Statistical Approach to optimization of Drying Conditions for a Transdermal Delivery System

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Abstract
The drying process is crucial in continuous manufacturing of matrix-type transdemual delivery systems (TDS) starting from solvent-based adhesives. In order to optimize the drying conditions of a TDS containing 22% of the partly volatile penetration enhancer 1,2-propanediol, the key factors drying time, which is reciprocal to the web speed, and drying temperature were optimized using the results of the statistical analysis of a two-factorial experiment. Thus, it was possible to reduce the amount of residual solvent ethyl acetate to below 0.02 % while the 1,2-propanediol content of the TDS was kept at the desired 22% level.