Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models
- 1 December 1998
- journal article
- research article
- Published by American Physiological Society in Physiology
- Vol. 13 (6) , 287-293
- https://doi.org/10.1152/physiologyonline.1998.13.6.287
Abstract
Endothelial cells exposed to inductive central nervous system factors differentiate into a blood-brain barrier phenotype. The blood-brain barrier frequently obstructs the passage of chemotherapeutics into the brain. Tissue culture systems have been developed to reproduce key properties of the intact blood-brain barrier and to allow for testing of mechanisms of transendothelial drug permeation.Keywords
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