Hayflick’s hypothesis: an approach to in vivo testing

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Abstract
The experimental evidence relating to the hypothesis of finite cellular life is reviewed. It is emphasized that even if somatic cell production were limited its total potential would have to be vast to provide for extensive cellular regeneration. The actual limit of reproductive cell life would therefore not likely be reached in a normal life-span. It is proposed to test the hypothesis by deliberate exhaustion of stem-cell reserve, and iron-55 cytocide is described as an experimental system that might be applicable.—Reincke, U., H. Burlington, E. P. Cronkite and J. Laissue. Hayflick’s hypothesis: an approach to in vivo testing. Federation Proc. 34: 71–75, 1975. Keywords Irradiate Mouse Renewal Capacity Human Diploid Cell Strain Human Hemopoiesis Stern Cell These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.