A monoclonal anti-DNA antibody also binds to cell-surface protein(s).

1 June 1984

journal article
research article
Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences

Vol. 81 (12) , 3843-3845
https://doi.org/10.1073/pnas.81.12.3843

Abstract

A murine monoclonal anti-DNA antibody (PME77) was found to bind tightly to the plasma membrane of Raji cells. This monoclonal anti-DNA antibody reacts in a radioimmunoassay with the cell surface of a variety of mammalian cell types and the antigenic determinant recognized by the monoclonal anti-DNA antibody at the surface of Raji cells is resistant to DNase. It belongs to polypeptides removed from the cell surface by a mild proteinase K treatment.

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