Further support for changes in chloroquine disposition and metabolism between a low and a high dose
- 1 January 1985
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 28 (6) , 721-722
- https://doi.org/10.1007/bf00607924
Abstract
The kinetics of chloroquine and its major metabolite desethylchloroquine were studied in patients with rheumatoid disease after single oral doses of chloroquine phosphate corresponding to 150 and 300 mg chloroquine base. The findings strengthen the previous finding that the disposition of chloroquine involves rate limiting steps.Keywords
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