A Series of New Sulfonamides Which Are Unaffected by p -Aminobenzoic Acid

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Abstract
A series of benzene sulfonic acid derivatives were tested for their in vitro effects against Types I, II and III pneumococci, Groups I and IIa menin-gococci, gonococcus, Streptococcus pyogenes (C-203), Staphylococcus aureus, Clostridium welchii, C. tetani and several Gram-negative enteric organisms. The Gram-positive cocci are inhibited to the greatest extent by sulfanilyl-3,5-dibromoanilide or sulfanilyl-3,5-dichloroanilide. These same compounds, together with benzenesulfon-3,5-dibromo-(or dichloro-) anilide, were active against the anaerobic clostridia. Aminoethylbenzenesulfon-3,5-dibromoanilide and ethane-sulfon-3,5-dibromoanilide inhibited the enteric organisms, while the Gram-negative cocci were affected by all the above compounds. A "sulfonamide-resistant" strain of the gonococcus was inhibited to almost as great a degree as "sulfonamide-susceptible" strains. The bacteriostatic activity of these compounds is not antagonized by the presence of p-aminobenzoic acid.

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