Serine Requirement in Leukemic and Normal Blood Cells
- 28 March 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 163 (3874) , 1452-1453
- https://doi.org/10.1126/science.163.3874.1452
Abstract
In a serine-deficient medium, cells from humangt chronic granulocytic leukemia and normal human bone marrow exhibited a marked inhibition of incorporation of-radioactive precursors of DNA, RNA, and protein into an acid insoluble cell fraction. Normal diploid human fibroblasts did not exhibit inhibition without serine. Chronic granulocytic leukemia and normal marrow cells were essentially unable to synthesize C14-serine from C14-glucose, while human diploid fibroblasts were highly capable of this synthesis.Keywords
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