Optimized Real-Time Quantitative PCR Measurement of Male Fetal DNA in Maternal Plasma
- 1 September 2005
- journal article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 51 (9) , 1598-1604
- https://doi.org/10.1373/clinchem.2005.051235
Abstract
Background: Circulating fetal DNA (cfDNA) in maternal plasma has been measured to investigate its possible relationship with pregnancy-related disorders, including fetal trisomy 21 and preeclampsia. The circulating concentrations of single-copy fetal genes, however, are close to the detection limits of PCR methods.Keywords
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